Basolateral Amygdala Lesions Abolish Orbitofrontal-Dependent Reversal Impairments

  title={Basolateral Amygdala Lesions Abolish Orbitofrontal-Dependent Reversal Impairments},
  author={Thomas A Stalnaker and Theresa M. Franz and Teghpal Singh and Geoffrey Schoenbaum},
Damage to orbitofrontal cortex (OFC) has long been associated with deficits in reversal learning. OFC damage also causes inflexible associative encoding in basolateral amygdala (ABL) during reversal learning. Here we provide a critical test of the hypothesis that the reversal deficit in OFC-lesioned rats is caused by this inflexible encoding in ABL. Rats with bilateral neurotoxic lesions of OFC, ABL, or both areas were tested on a series of two-odor go/no-go discrimination problems, followed by… CONTINUE READING
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Bilateral orbital prefrontal cortex lesions in rhesus monkeys disrupt choices guided by both reward value and reward contingency.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 2004
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