Basket Studies: Redefining Clinical Trials in the Era of Genome-Driven Oncology.

Abstract

Understanding a tumor's detailed molecular profile has become increasingly necessary to deliver the standard of care for patients with advanced cancer. Innovations in both tumor genomic sequencing technology and the development of drugs that target molecular alterations have fueled recent gains in genome-driven oncology care. "Basket studies," or histology… (More)
DOI: 10.1146/annurev-med-062016-050343