Basis of beneficial immunomodulation by monoclonal antibodies against Streptococcus mutans adhesin P1.

@article{Isoda2007BasisOB,
  title={Basis of beneficial immunomodulation by monoclonal antibodies against Streptococcus mutans adhesin P1.},
  author={Ryutaro Isoda and Rebekah A. Robinette and Trina L. Pinder and William P. McArthur and L. Jeannine Brady},
  journal={FEMS immunology and medical microbiology},
  year={2007},
  volume={51 1},
  pages={102-11}
}
We previously identified five monoclonal antibodies (MAbs) against Streptococcus mutans adhesin P1 that modulate the humoral response when bound to whole bacteria and immune complexes (ICs) are administered to BALB/c mice. The two MAbs that redirected the response towards increased efficacy recognize discontinuous epitopes involving pre-alanine-rich domain… CONTINUE READING