Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.

  title={Basis of CTLA-4 function in regulatory and conventional CD4(+) T cells.},
  author={Xuguang Tai and François Van Laethem and Leonid A. Pobezinsky and Terry I. Guinter and Susan O. Sharrow and Anthony G Adams and Larry Granger and Michael J. Kruhlak and Tullia Lindsten and Craig B Thompson and L. Feigenbaum and Alfred Singer},
  volume={119 22},
CTLA-4 proteins contribute to the suppressor function of regulatory T cells (Tregs), but the mechanism by which they do so remains incompletely understood. In the present study, we assessed CTLA-4 protein function in both Tregs and conventional (Tconv) CD4(+) T cells. We report that CTLA-4 proteins are responsible for all 3 characteristic Treg functions of suppression, TCR hyposignaling, and anergy. However, Treg suppression and anergy only required the external domain of CTLA-4, whereas TCR… CONTINUE READING


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