Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor.

@article{Dong1990BasisFL,
  title={Basis for low affinity binding of a lysosomal cysteine protease to the cation-independent mannose 6-phosphate receptor.},
  author={Jing Ming Dong and Gary Sahagian},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 8},
  pages={
          4210-7
        }
}
In cultured mouse fibroblasts, secretion of the lysosomal cysteine protease, MEP (major excreted protein) is regulated by growth factors and viral transformation. The ability of this protein to be regulated has been attributed to its intrinsic low affinity for the cation-independent mannose 6-phosphate (Man-6-P) receptor (Dong, J., Prence, E. M., and Sahagian, G. G. (1989) J. Biol. Chem. 264, 7377-7383). In this study, the basis for this low affinity was examined. Chromatography on a cation… CONTINUE READING

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