Basic properties and molecular mechanisms of exogenous chemical carcinogens.

  title={Basic properties and molecular mechanisms of exogenous chemical carcinogens.},
  author={Philippe Irigaray and Dominique Belpomme},
  volume={31 2},
Exogenous chemical carcinogenesis is an extremely complex multifactorial process during which gene-environment interactions involving chronic exposure to exogenous chemical carcinogens (ECCs) and polymorphisms of cancer susceptibility genes add further complexity. We describe the properties and molecular mechanisms of ECCs that contribute to induce and generate cancer. A basic and specific property of many lipophilic organic ECCs including polycyclic aromatic hydrocarbons and polyhalogenated… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 34 extracted citations


Publications referenced by this paper.
Showing 1-10 of 111 references

Molecular determinants of species - specific agonist and antagonist activity of a substituted flavone towards the aryl hydrocarbon receptor

  • E. C. Henry
  • Arch . Biochem . Biophys .
  • 2008

Possible involvement of oxidative stress in trichloroethyleneinduced genotoxicity in human HepG 2 cells

  • I. N. Pérez-Maldonado
  • Mutat . Res .
  • 2008

Association of the GSTP 1 and NQO 1 polymorphisms and head and neck squamous cell carcinoma risk

  • R. A. Cartwright
  • J . Korean Med . Sci .
  • 2006

Similar Papers

Loading similar papers…