Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations.

@article{Boyle2000BasicMO,
  title={Basic mechanisms of DNA-raised antibody responses to intramuscular and gene gun immunizations.},
  author={Chris Boyle and Harriet L Robinson},
  journal={DNA and cell biology},
  year={2000},
  volume={19 3},
  pages={157-65}
}
DNA-raised antibody (Ab) responses have been compared for the dependence on CD4+ and CD8+ cells, the longevity of functional antigen (Ag) expression, and the nature of the Ag-presenting cell after intramuscular (i.m.) and gene gun inoculations. A plasmid expressing the hemagglutinin (HA) glycoprotein of influenza virus was used for immunizations of BALB/c mice. Intramuscular and gene gun-raised Abs had similar dependencies on CD4+ and CD8+ cells but different temporal patterns of functional Ag… CONTINUE READING

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