Basic mechanisms in heart failure: the cytokine hypothesis.

  title={Basic mechanisms in heart failure: the cytokine hypothesis.},
  author={Yukihiro Seta and Kesavan Shan and Biykem Bozkurt and Hakan Oral and Douglas L. Mann},
  journal={Journal of cardiac failure},
  volume={2 3},
Although the development and progression of heart failure have traditionally been viewed as hemodynamic disorders, there is now an increasing awareness that the syndrome of heart failure cannot be simply and/or precisely defined solely in hemodynamic terms. The inability of the so-called hemodynamic hypothesis to explain the progression of heart failure has given rise to the notion that heart failure may progress as a result of the overexpression of an ensemble of biologically active molecules… CONTINUE READING

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