Basic mechanisms and clinical implications of peritoneal fibrosis.

  title={Basic mechanisms and clinical implications of peritoneal fibrosis.},
  author={Peter J Margetts and Philippe Bonniaud},
  journal={Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis},
  volume={23 6},
We have stressed the role of certain growth factors and cytokines in peritoneal fibrosis, including TGFbeta, TIMP-1, and inflammatory cytokines, especially IL-1beta. Recent research highlights the myofibroblast-like transformation of mesothelial cells as a central initiating event in peritoneal fibrosis. The induction, survival, and apoptosis of the myofibroblast cell population likely dictate the nature of the fibrogenic response. The accumulation of collagen occurs in a nondegradative… CONTINUE READING


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