Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression.

@article{Sato2008BasichelixloophelixT,
  title={Basic-helix-loop-helix (bHLH) transcription factor DEC2 negatively regulates vascular endothelial growth factor expression.},
  author={Fuyuki Sato and U K Bhawal and Takeshi Kawamoto and Katsumi Fujimoto and Tadaatsu Imaizumi and Tadanobu Imanaka and Jun Kondo and Satoru Koyanagi and Mitsuhide Noshiro and Hidemi Yoshida and Tomomi Kusumi and Yukio Kato and Hiroshi Kijima},
  journal={Genes to cells : devoted to molecular & cellular mechanisms},
  year={2008},
  volume={13 2},
  pages={131-44}
}
DEC1 (BHLHB2/Sharp2/Stra13) and DEC2 (BHLHB3/Sharp1) are basic-helix-loop-helix (bHLH) transcription factors, involved in cellular differentiation, responses to hypoxia and circadian rhythms. We recently showed that the expression of DEC1 and DEC2 was up-regulated by hypoxia; however, the functions of these two factors under hypoxic conditions have not been elucidated in detail. It is well established that the expression of vascular endothelial growth factor (VEGF) is up-regulated by hypoxia… CONTINUE READING
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