Basic fibroblast growth factor released from a platinum coil with a polyvinyl alcohol core enhances cellular proliferation and vascular wall thickness: an in vitro and in vivo study.

@article{Matsumoto2003BasicFG,
  title={Basic fibroblast growth factor released from a platinum coil with a polyvinyl alcohol core enhances cellular proliferation and vascular wall thickness: an in vitro and in vivo study.},
  author={Hiroyuki Matsumoto and Teruhisa Terada and Mitsuharu Tsuura and Toru Itakura and Atsushi Ogawa},
  journal={Neurosurgery},
  year={2003},
  volume={53 2},
  pages={
          402-7; discussion 407-8
        }
}
OBJECTIVE We developed a new type of platinum coil that has a polyvinyl alcohol (PVA) core to absorb and release various biologically active materials for the endovascular treatment of intracranial aneurysms. We evaluated its efficacy as an embolic material with basic fibroblast growth factor (bFGF) in an in vitro and in vivo study. METHODS A small PVA thread was inserted into the central space of the primary coil. This coil was named the PVA-core coil. Ten-millimeter segments of the PVA-core… CONTINUE READING
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