Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord.

@article{Meijs2004BasicFG,
  title={Basic fibroblast growth factor promotes neuronal survival but not behavioral recovery in the transected and Schwann cell implanted rat thoracic spinal cord.},
  author={Matthijs F L Meijs and Leonardus Timmers and Damien D Pearse and Patrick A. Tresco and Margaret Longest Bates and Elbert A. J. Joosten and Mary Bartlett Bunge and Martin Oudega},
  journal={Journal of neurotrauma},
  year={2004},
  volume={21 10},
  pages={1415-30}
}
It was investigated whether the addition of basic fibroblast growth factor (FGF-2) enhances the efficacy of a Schwann cell (SC) bridge to repair the transected spinal cord by assessing tissue sparing and neuronal survival near the graft-cord interfaces, axonal regeneration and myelination in the graft, and behavioral recovery up to 12 weeks post-grafting. Experimental animals received a bridge of SCs within fibrin containing 1 microg of FGF-2; control animals received a SC implant without FGF-2… CONTINUE READING