Basic fibroblast growth factor is a key factor that induces bone marrow mesenchymal stem cells towards cells with Schwann cell phenotype.

@article{Jin2014BasicFG,
  title={Basic fibroblast growth factor is a key factor that induces bone marrow mesenchymal stem cells towards cells with Schwann cell phenotype.},
  author={Hongbo Jin and Aizhen Yang and Jinfeng Du and Dong-hui Li and Mei Liu and Fei Ding and Xiaosong Gu and Yan Liu},
  journal={Neuroscience letters},
  year={2014},
  volume={559},
  pages={82-7}
}
Bone marrow mesenchymal stem cells (MSCs) can be differentiate towards a Schwann cells (SCs) lineage when exposed to pre-inducing reagents β-mercaptoethanol (BME) and retinoic acid (RA), followed by inducing factors: forskolin (FSK), basic fibroblast growth factor (bFGF), platelet derived growth factor (PDGF), and heregulin (HRG). However, the underlying mechanisms remain unclear. Here, we investigated the individual effects of these inducing factors on the differentiation of MSCs towards SC… CONTINUE READING

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