Basic fibroblast growth factor induces retinal pigment epithelium to generate neural retina in vitro.

@article{Pittack1991BasicFG,
  title={Basic fibroblast growth factor induces retinal pigment epithelium to generate neural retina in vitro.},
  author={C Pittack and Marius Jones and Thomas A. Reh},
  journal={Development},
  year={1991},
  volume={113 2},
  pages={577-88}
}
During embryogenesis, the cells of the eye primordium are initially capable of giving rise to either neural retina or pigmented epithelium (PE), but become restricted to one of these potential cell fates. However, following surgical removal of the retina in embryonic chicks and larval amphibians, new neural retina is generated by the transdifferentiation, or phenotypic switching, of PE cells into neuronal progenitors. A recent study has shown that basic fibroblast growth factor (bFGF… CONTINUE READING
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