Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes

Abstract

Basic fibroblast growth factor (bFGF or FGF-2) is produced by nearly all melanomas in vitro and in vivo but not by normal melanocytes, which require exogenous bFGF for growth. In this study, we transduced normal human melanocytes to overexpress two forms of bFGF: (bFGF-Long and bFGF-Short) using replication-deficient adenovirus 5 vectors. bFGF-Long induced… (More)
DOI: 10.1038/sj.onc.1203066

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@article{Nesbit1999BasicFG, title={Basic fibroblast growth factor induces a transformed phenotype in normal human melanocytes}, author={Mark Nesbit and Heike KE Nesbit and Jean Bennett and Thomas Andl and Mei-Yu Hsu and Emma Dejesus and Michelle McBrian and Abha R. Gupta and Stephen L. Eck and Meenhard Herlyn}, journal={Oncogene}, year={1999}, volume={18}, pages={6469-6476} }