Basic fibroblast growth factor in HIV-associated hemolytic uremic syndrome

@article{Ray1999BasicFG,
  title={Basic fibroblast growth factor in HIV-associated hemolytic uremic syndrome},
  author={Patricio E. Ray and Xue-hui Liu and Lian Xu and Tamara Rakusan},
  journal={Pediatric Nephrology},
  year={1999},
  volume={13},
  pages={586-593}
}
Endothelial injury is the primary pathogenic event leading to the renal thrombotic microangiopathic lesions typical of the hemolytic uremic syndrome (HUS). Basic fibroblast growth factor (bFGF) is an angiogenic growth factor released by injured endothelial cells. In a previous study we have found a significant accumulation of bFGF in human immunodeficiency virus (HIV)-transgenic mice with renal disease. Here we investigated whether bFGF was accumulated in the circulation and kidneys of two… CONTINUE READING