Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition.

@article{Bouche1987BasicFG,
  title={Basic fibroblast growth factor enters the nucleolus and stimulates the transcription of ribosomal genes in ABAE cells undergoing G0----G1 transition.},
  author={G{\'e}rard Bouche and Nicole Gas and H. Prats and V{\'e}ronique Baldin and J. P. Tauber and Justin Teissi{\'e} and François Amalric},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1987},
  volume={84 19},
  pages={
          6770-4
        }
}
The cellular action of growth factors, among them basic fibroblast growth factor (bFGF), is mediated by their interaction with a cell surface receptor, but the mechanism of transfer of mitogenic (or other) signals to the nucleus has not been identified. In this work, we show that bFGF is translocated to and accumulated in the nucleolus. Furthermore, the nucleolar localization of bFGF is correlated with a stimulation of transcription of ribosomal genes during G0----G1 transition induced by bFGF… CONTINUE READING

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