Basic fibroblast growth factor causes growth arrest in MCF-7 human breast cancer cells while inducing both mitogenic and inhibitory G1 events.

@article{Wang1997BasicFG,
  title={Basic fibroblast growth factor causes growth arrest in MCF-7 human breast cancer cells while inducing both mitogenic and inhibitory G1 events.},
  author={Hui-Yun Wang and Mark A. Rubin and Eyal Fenig and Anthony Deblasio and John Mendelsohn and Joachim Yahalom and Robert Wieder},
  journal={Cancer research},
  year={1997},
  volume={57 9},
  pages={1750-7}
}
Basic fibroblast growth factor (bFGF), a classical mitogen in fibroblasts and endothelial cells, inhibits the proliferation of MCF-7 and other human breast cancer cell lines. To explain this paradoxic effect, we investigated the effects of bFGF on cyclins and protein members of cyclin complexes that exert positive and negative control on the progression of cells through the G1 phase of the cell cycle. bFGF induced an increase in cyclin D1, cyclin E, and cyclin-dependent kinase 4 (cdk4) protein… CONTINUE READING

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