Basic fibroblast growth factor antagonizes transforming growth factor-beta1-induced smooth muscle gene expression through extracellular signal-regulated kinase 1/2 signaling pathway activation.

@article{KawaiKowase2004BasicFG,
  title={Basic fibroblast growth factor antagonizes transforming growth factor-beta1-induced smooth muscle gene expression through extracellular signal-regulated kinase 1/2 signaling pathway activation.},
  author={Keiko Kawai-Kowase and Hiroko Sato and Yuko Oyama and Hiroyoshi Kanai and Mahito Sato and Hiroshi Doi and Masahiko Kurabayashi},
  journal={Arteriosclerosis, thrombosis, and vascular biology},
  year={2004},
  volume={24 8},
  pages={1384-90}
}
OBJECTIVE Transforming growth factor-beta1 (TGFbeta1) and fibroblast growth factor (FGF) families play a pivotal role during vascular development and in the pathogenesis of vascular disease. However, the interaction of intracellular signaling evoked by each of these growth factors is not well understood. The present study was undertaken to examine the molecular mechanisms that mediate the effects of TGFbeta1 and basic FGF (bFGF) on smooth muscle cell (SMC) gene expression. METHODS AND RESULTS… CONTINUE READING

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