Basic concepts in RNA virus evolution

@article{Domingo1996BasicCI,
  title={Basic concepts in RNA virus evolution},
  author={Esteban Domingo and Cristina Escarmís and Noem{\'i} Sevilla and Andr{\'e}s Moya and Santiago F. Elena and Josep Quer and Isabel S. Novella and John J. Holland},
  journal={The FASEB Journal},
  year={1996},
  volume={10},
  pages={859 - 864}
}
A hallmark of RNA genomes is the error‐prone nature of their Replication and retro‐ transcription. The major biochemical basis of the limited replication fidelity is the absence of proof‐ reading/repair and postreplicative error correction mechanisms that normally operate during replication of cellular DNA. In spite of this unique feature of RNA replicons, the dynamics of viral populations seems to follow the same basic principles that classical population genetics has established for higher… Expand

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