Basic concepts and methods for joint models of longitudinal and survival data.

@article{Ibrahim2010BasicCA,
  title={Basic concepts and methods for joint models of longitudinal and survival data.},
  author={Joseph G. Ibrahim and Haitao Chu and L. M. Chen},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  year={2010},
  volume={28 16},
  pages={
          2796-801
        }
}
Joint models for longitudinal and survival data are particularly relevant to many cancer clinical trials and observational studies in which longitudinal biomarkers (eg, circulating tumor cells, immune response to a vaccine, and quality-of-life measurements) may be highly associated with time to event, such as relapse-free survival or overall survival. In this article, we give an introductory overview on joint modeling and present a general discussion of a broad range of issues that arise in the… CONTINUE READING
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