Basic concept of development and practical application of animal models for human diseases.

@article{Nomura2008BasicCO,
  title={Basic concept of development and practical application of animal models for human diseases.},
  author={Tatsuji Nomura and Norikazu Tamaoki and Akira Takakura and Hiroshi Suemizu},
  journal={Current topics in microbiology and immunology},
  year={2008},
  volume={324},
  pages={1-24}
}
The "humanized mouse" is a mouse harboring functioning human tissues used as in vivo human models for both physiological and pathological conditions. The NOD/Shi-scid IL2rgamma(null) (NOG) mouse, an excellent immunodeficient mouse used as the basis for the humanized mouse, requires strict genetic and environmental control for production and use in experiments. Genetic control using marker-assisted selection is described. In addition, NOG mice are easily affected by microbiological and proximate… CONTINUE READING

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