Basic and translational research on proteinase-activated receptors: antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic disease.

@article{Chintala2008BasicAT,
  title={Basic and translational research on proteinase-activated receptors: antagonism of the proteinase-activated receptor 1 for thrombin, a novel approach to antiplatelet therapy for atherothrombotic disease.},
  author={Madhu S. Chintala and Kenji Shimizu and Masami Ogawa and Hiroya Yamaguchi and Masaki Doi and Peder Jens Jensen},
  journal={Journal of pharmacological sciences},
  year={2008},
  volume={108 4},
  pages={433-8}
}
Atherothrombotic disease is a leading public health problem. Although current antiplatelet agents, such as aspirin and adenosine diphosphate (ADP)-receptor antagonists, reduce the morbidity and mortality associated with atherothrombotic disease, the residual risk for ischemic events remains substantial. The high residual risk despite dual antiplatelet therapy can be attributed to the fact that platelets possess multiple pathways of activation that are not all inhibited by aspirin and ADP… CONTINUE READING

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