Basic and acidic fibroblast growth factors interact with the same cell surface receptors.

@article{Neufeld1986BasicAA,
  title={Basic and acidic fibroblast growth factors interact with the same cell surface receptors.},
  author={Gera Neufeld and Denis Gospodarowicz},
  journal={The Journal of biological chemistry},
  year={1986},
  volume={261 12},
  pages={5631-7}
}
Despite quantitative differences, the activity of basic and acidic fibroblast growth factors (FGF) on a wide variety of normal diploid cells derived from neuroectoderm and mesoderm is intrinsically similar. This suggests that they bind to the same cell surface receptors. This was investigated using a baby hamster kidney cell line (BHK-21) as a model. BHK-21 cell membrane components that interact with basic and acidic FGF have been identified by covalent cross-linking to their respective 125I… CONTINUE READING
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