Basic Pharmacology of Valproate
@article{Lscher2002BasicPO, title={Basic Pharmacology of Valproate}, author={Wolfgang L{\"o}scher}, journal={CNS Drugs}, year={2002}, volume={16}, pages={669-694} }
Since its first marketing as an antiepileptic drug (AED) 35 years ago in France, valproate has become established worldwide as one of the most widely used AEDs in the treatment of both generalised and partial seizures in adults and children. The broad spectrum of antiepileptic efficacy of valproate is reflected in preclinical in vivo and in vitro models, including a variety of animal models of seizures or epilepsy.There is no single mechanism of action of valproate that can completely account…
412 Citations
Suivi thrapeutique pharmacologique du valproate
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Several studies show a concentration-effect relationship, but two interventional trials ended in the lack of interest of the Therapeutic Drug Monitoring (TDM), although it is of current practice, however, numerous drug interactions may modify the plasma concentrations of valproate.
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Characterizing the mechanisms of action of the present antiepileptic medications would increase the understanding for the pathophysiological mechanisms of epileptic seizures, as well as the development of new therapeutic strategies.
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Valproate appears to have a very low potential for pharmacodynamic paradoxical seizure aggravation, unlike most AEDs, including the newer ones.
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- Biology, PsychologyEpilepsia
- 2005
Although valproate is considered to be the drug of first choice for the treatment of idiopathic generalized epilepsies (IGEs), other antiepileptic drugs (AEDs), both old and new, are also available and levetiracetam is unique in that it may act via a specific binding site in the brain.
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