Basic Pharmacology of Valproate

@article{Lscher2002BasicPO,
  title={Basic Pharmacology of Valproate},
  author={Wolfgang L{\"o}scher},
  journal={CNS Drugs},
  year={2002},
  volume={16},
  pages={669-694}
}
Since its first marketing as an antiepileptic drug (AED) 35 years ago in France, valproate has become established worldwide as one of the most widely used AEDs in the treatment of both generalised and partial seizures in adults and children. The broad spectrum of antiepileptic efficacy of valproate is reflected in preclinical in vivo and in vitro models, including a variety of animal models of seizures or epilepsy.There is no single mechanism of action of valproate that can completely account… 
Suivi thrapeutique pharmacologique du valproate
TLDR
Several studies show a concentration-effect relationship, but two interventional trials ended in the lack of interest of the Therapeutic Drug Monitoring (TDM), although it is of current practice, however, numerous drug interactions may modify the plasma concentrations of valproate.
Valproic acid: Second generation
Basic Mechanisms of Action of the Antiepileptic Drugs
TLDR
Characterizing the mechanisms of action of the present antiepileptic medications would increase the understanding for the pathophysiological mechanisms of epileptic seizures, as well as the development of new therapeutic strategies.
Valproic Acid and Epilepsy: From Molecular Mechanisms to Clinical Evidences
TLDR
Since VPA modulates DNA transcription through HDACs, recent evidences point to its use as an anti-nociceptive in migraine prophylaxis, and, even more interestingly, as a positive modulator of chemotherapy in cancer treatment.
Antiepileptic Drug-Induced Pharmacodynamic Aggravation of Seizures
TLDR
Valproate appears to have a very low potential for pharmacodynamic paradoxical seizure aggravation, unlike most AEDs, including the newer ones.
Selected classical and novel antiepileptic drugs – mechanisms of action, neuroprotection, and effectiveness in epileptic and non-epileptic conditions
TLDR
Around 30% of epileptic patients do not substantially benefit from AEDs, and it is possible that rational combinations of Aeds, based upon experimental studies, could improve this outcome.
Properties of Antiepileptic Drugs in the Treatment of Idiopathic Generalized Epilepsies
TLDR
Although valproate is considered to be the drug of first choice for the treatment of idiopathic generalized epilepsies (IGEs), other antiepileptic drugs (AEDs), both old and new, are also available and levetiracetam is unique in that it may act via a specific binding site in the brain.
Mechanisms of action of currently used antiseizure drugs
Pharmacotherapy of epilepsy: New armamentarium, new issues
  • F. Vajda
  • Medicine, Psychology
    Journal of Clinical Neuroscience
  • 2007
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 165 REFERENCES
Mechanisms of action of valproate: a commentatory
Pharmacological and Therapeutic Properties of Valproate
TLDR
Valproate is generally regarded as a first-choice agent for most forms of idiopathic and symptomatic generalised epilepsies, and prescription of a broad-spectrum drug such as valproate has clear advantages in this situation.
Valproic acid. A reappraisal of its pharmacological properties and clinical efficacy in epilepsy.
TLDR
Comparative trials and extensive clinical experience have demonstrated the efficacy and tolerability of valproic acid and support its role as a valuable and well established first-line treatment for patients with a broad range of seizure types.
Valproate: Recent Findings and Perspectives
TLDR
The pharmacological effects of some analogues and metabolites, the newest findings concerning the γ‐aminobutyric acid (GABA) hypothesis, and the possible involvement of valproate with ionic processes related to the intrinsic mechanisms of epilepsy at the cellular level are presented.
The discovery of valproate
TLDR
The researchers found that the vehicle, valproate, alone exerted an anticonvulsant effect in the pentylenetetrazole (PTZ) seizure test.
New visions in the pharmacology of anticonvulsion.
  • W. Löscher
  • Biology, Medicine
    European journal of pharmacology
  • 1998
Valproic Acid
TLDR
Valproic acid has demonstrated considerable potential as a first-line therapy for the management of bipolar or schizoaffective disorder, particularly for patients resistant to, or intolerant of, lithium or carbamazepine and those with rapid cycling or mixed mania.
...
1
2
3
4
5
...