Basic Pharmacology of Valproate

  title={Basic Pharmacology of Valproate},
  author={W. L{\"o}scher},
  journal={CNS Drugs},
  • W. Löscher
  • Published 2002
  • Medicine
  • CNS Drugs
  • Since its first marketing as an antiepileptic drug (AED) 35 years ago in France, valproate has become established worldwide as one of the most widely used AEDs in the treatment of both generalised and partial seizures in adults and children. The broad spectrum of antiepileptic efficacy of valproate is reflected in preclinical in vivo and in vitro models, including a variety of animal models of seizures or epilepsy.There is no single mechanism of action of valproate that can completely account… CONTINUE READING
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