Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization

@article{Franco2016BasicPA,
  title={Basic Pharmacological and Structural Evidence for Class A G-Protein-Coupled Receptor Heteromerization},
  author={Rafael Franco and Eva Mart{\'i}nez-Pinilla and Jos{\'e} L Lanciego and Gemma Navarro},
  journal={Frontiers in pharmacology},
  year={2016},
  volume={7},
  pages={76}
}
Cell membrane receptors rarely work on isolation, often they form oligomeric complexes with other receptor molecules and they may directly interact with different proteins of the signal transduction machinery. For a variety of reasons, rhodopsin-like class A G-protein-coupled receptors (GPCRs) seem an exception to the general rule of receptor-receptor direct interaction. In fact, controversy surrounds their potential to form homo- hetero-dimers/oligomers with other class A GPCRs; in a sense… CONTINUE READING