Basic Pharmacokinetics of Bisoprolol, a New Highly Beta1‐selective Adrenoceptor Antagonist

@article{Leopold1986BasicPO,
  title={Basic Pharmacokinetics of Bisoprolol, a New Highly Beta1‐selective Adrenoceptor Antagonist},
  author={G. Leopold and Joachim Pabst and W. Ungeth{\"u}m and K. U. B{\"u}hring},
  journal={The Journal of Clinical Pharmacology},
  year={1986},
  volume={26}
}
The basic pharmacokinetics of bisoprolol were investigated in three independent studies involving 23 healthy volunteers. After administering 20 mg of 14C‐bisoprolol orally, mean elimination half‐lives of 11 hours for the unchanged drug and 12 hours for total radioactivity were observed. The enteral absorption of bisoprolol was nearly complete. Fifty percent of the dose was eliminated renally as unchanged bisoprolol and the other 50% metabolically, with subsequent renal excretion of the… Expand
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