Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats

@article{Nozaki1993BasicFG,
  title={Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats},
  author={Kazuhiko Nozaki and Seth P. Finklestein and M. Flint Beal},
  journal={Journal of Cerebral Blood Flow \& Metabolism},
  year={1993},
  volume={13},
  pages={221 - 228}
}
Basic fibroblast growth factor (bFGF) is a polypeptide that promotes neuronal survival and blocks excitatory amino acid (EAA) neurotoxicity in vitro at very low concentrations. In the present study, we examined whether systemically administered bFGF could prevent neuronal damage induced by either EAAs or hypoxia–ischemia in vivo. Neuroprotective effects were examined in a neonatal model of hypoxia–ischemia (unilateral ligation of the carotid artery followed by exposure to 8% oxygen for 1.5 h… 

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