Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats
@article{Nozaki1993BasicFG, title={Basic Fibroblast Growth Factor Protects against Hypoxia-Ischemia and NMDA Neurotoxicity in Neonatal Rats}, author={Kazuhiko Nozaki and Seth P. Finklestein and M. Flint Beal}, journal={Journal of Cerebral Blood Flow \& Metabolism}, year={1993}, volume={13}, pages={221 - 228} }
Basic fibroblast growth factor (bFGF) is a polypeptide that promotes neuronal survival and blocks excitatory amino acid (EAA) neurotoxicity in vitro at very low concentrations. In the present study, we examined whether systemically administered bFGF could prevent neuronal damage induced by either EAAs or hypoxia–ischemia in vivo. Neuroprotective effects were examined in a neonatal model of hypoxia–ischemia (unilateral ligation of the carotid artery followed by exposure to 8% oxygen for 1.5 h…
215 Citations
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References
SHOWING 1-10 OF 84 REFERENCES
Basic fibroblast growth factor protects striatal neurons in vitro from NMDA-receptor mediated excitotoxicity
- Biology, ChemistryBrain Research
- 1992
Failure of basic fibroblast growth factor to prevent postischemic neuronal damage in the rat.
- BiologyEuropean journal of pharmacology
- 1991
MK-801 protects the neonatal brain from hypoxic-ischemic damage.
- Biology, MedicineEuropean journal of pharmacology
- 1987
Neuroprotective Effects of L-Kynurenine on Hypoxia—Ischemia and NMDA Lesions in Neonatal Rats
- Biology, MedicineJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
- 1992
Results show for the first time that pharmacologic manipulation of endogenous concentrations of kynurenic acid can exert neuroprotective effects and dose-dependently protected against NMDA neurotoxicity in 7-day-old rats.
NGF and bFGF protect rat hippocampal and human cortical neurons against hypoglycemic damage by stabilizing calcium homeostasis
- BiologyNeuron
- 1991
Fibroblast growth factor and glutamate: opposing roles in the generation and degeneration of hippocampal neuroarchitecture
- BiologyThe Journal of neuroscience : the official journal of the Society for Neuroscience
- 1989
Interactions between growth factors and neurotransmitters may be important in brain development; imbalances in these systems may lead to neurodegeneration; and cellular calcium-regulating systems may be a common focus of growth factor and neurotransmitter actions.
Sensitivity of the developing rat brain to hypobaric/ischemic damage parallels sensitivity to N-methyl-aspartate neurotoxicity
- BiologyThe Journal of neuroscience : the official journal of the Society for Neuroscience
- 1989
There may be a period during development when NMA receptors are hypersensitive to excitotoxic stimulation, thus rendering the neurons possessing such receptors hypervulnerable to hypoxic/ischemic brain damage.
Intracerebral implantation of nerve growth factor-producing fibroblasts protects striatum against neurotoxic levels of excitatory amino acids
- BiologyNeuroscience
- 1991
Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo
- BiologyNature
- 1988
It is demonstrated that basic fibroblast growth factor administered into the brain reduces the death of cholinergic neurons in the medial septum and diagonal band of Broca after transection of their axons, in both young adult and aged rats.
Basic fibroblast growth factor promotes the survival and development of mesencephalic neurons in culture.
- BiologyDevelopmental biology
- 1989