Basic Fibroblast Growth Factor Gene Expression

  title={Basic Fibroblast Growth Factor Gene Expression},
  author={Robert Z. Florkiewicz and F Shibata and Teresa J. Barankiewicz and Andre Baird and A. M. Gonz{\'a}lez and Elin Florkiewicz and Najmul Shah},
  journal={Annals of the New York Academy of Sciences},

HOXB7 constitutively activates basic fibroblast growth factor in melanomas

A key role for constitutive HOXB7 expression in melanoma cell proliferation via basic fibroblast growth factor (bFGF) mRNA is indicated and the results raise the possibility that growth factor genes are critical HOX target genes in other developmental and/or neoplastic cell systems.

BTN3A3 inhibits the proliferation, migration and invasion of ovarian cancer cells by regulating ERK1/2 phosphorylation

BTN3A3 interacts with FGF2, which inhibits F GF2/ERK1/2 axis and ultimately inhibits the proliferation, migration and invasion of ovarian cancer cells.

Review of the Studies on the Anti-Tumoral Effect of Prunella vulgaris

  • W. Mak
  • Biology
    Journal of Biosciences and Medicines
  • 2021
The aim of this article was to summarize on what molecular mechanisms, which these previous research found responsible for the anti-tumoral effect of PV.

Functional Roles of FGF Signaling in Early Development of Vertebrate Embryos

This review discussed the functional roles of FGFs and their interacting partners as part of the gene regulatory network for germ layer specification, dorsal–ventral (DV), and anterior-posterior (AP) patterning, and briefly reviewed the regulatory molecules and pharmacological agents discovered that may allow modulation of F GF signaling in research.

The synthetic progesterone Norgestrel is neuroprotective in stressed photoreceptor‐like cells and retinal explants, mediating its effects via basic fibroblast growth factor, protein kinase A and glycogen synthase kinase 3β signalling

The results indicate that the protective efficacy of Norgestrel is, at least in part, due to the bFGF‐mediated activation of the PKA pathway, with subsequent inactivation of GSK3β.

Altered molecular pattern of mucosal healing in Crohn's disease fibrotic stenosis.

Fibrotic stenosis of CD may be the final result of an irreversible transformation of different cells into fibrogenic phenotype no longer inhibited by post-transcriptional regulation.

Why are breast cancer stem cells resistant to radiation

The results suggest that low DNA repair capacity is responsible for the high radiosensitivity of these CSC-like cells.

FGF2 (fibroblast growth factor 2 (basic))

Review on FGF2 (fibroblast growth factor 2 (basic)), with data on DNA, on the protein encoded, and where the gene is implicated.

Modification of fibrin to improve applications in regenerative medicine

Die Methode von Tissue Engineering oder der Gewebezuchtung drangt uns Matrizen oder Stutzgeruste , die Gewebearten imitieren in vitro zu entwickeln. Tissue Engineering setzt die Prasenz von sich



Activity of two different silencer elements of the chicken lysozyme gene can be compensated by enhancer elements.

An inverse linear relationship between the transcriptional activity of the tested constructs and the potential inhibition by the silencer elements was found: weak transcription units can be strongly repressed, whereas strong transcriptionunits can be only weakly repressed.

Human basic fibroblast growth factor: nucleotide sequence and genomic organization.

Southern blot analysis of human genomic DNA and mapping of the cloned gene shows that there is only one basic FGF gene, and all of the basic, heparin‐binding endothelial cell mitogens of similar amino acid composition that have been described must be products of this single gene.

A FOS protein is present in a complex that binds a negative regulator of MYC.

It is reported that a negative regulator of the human proto-oncogene MYC comprises no more than 26 bp of DNA, with sequence that resembles the regulators of at least two other genes, and nuclear factors that interact with the regulator are described.

Regulation of multiple basic fibroblast growth factor messenger ribonucleic acid transcripts by protein kinase C activators.

The human astrocytoma cell line U87-MG expressed two major basic fibroblast growth factor mRNA transcripts of 7.0 and 3.7 kilobase, and FGF mRNA levels were stimulated to a similar extent by platelet-derived growth factor or the synthetic diacylglycerol analog 1-oleoyl-2-acetyl-rac glycerol at doses which stimulated DNA synthesis in these cells.

Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.

It is demonstrated that the proto-oncogene product of c-jun interacts directly with specific target DNA sequences to regulate gene expression, and therefore it may now be possible to identify genes under the control ofc-jun that affect cell growth and neoplasia.

A single N-linked oligosaccharide at either of the two normal sites is sufficient for transport of vesicular stomatitis virus G protein to the cell surface

The nonglycosylated G protein synthesized when both glycosylation sites were eliminated did not reach the cell surface, but did appear to reach a Golgi-like region, as determined by indirect immunofluorescence microscopy.