Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation.

@article{Sellke1994BasicFE,
  title={Basic FGF enhances endothelium-dependent relaxation of the collateral-perfused coronary microcirculation.},
  author={Frank W Sellke and San Y Wang and Mitchell Friedman and Ken-ichi Harada and Elazer R. Edelman and William F Grossman and Michael Simons},
  journal={The American journal of physiology},
  year={1994},
  volume={267 4 Pt 2},
  pages={H1303-11}
}
The effect of chronic, periadventitial administration of basic (b) fibroblast growth factor (FGF) on endothelial dysfunction in the collateral-dependent and normally perfused coronary microcirculation was examined. Ameroid constrictors were placed on the proximal left circumflex coronary artery (LCX) in 23 pigs. In 11 pigs, bFGF was released from calcium alginate microcapsules into the perivascular space of the proximal left anterior descending coronary artery (LAD) and LCX. After 5-8 wk… CONTINUE READING