Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Phenotype Markers in Primary Human Chondrocytes by a Calcium/Calmodulin Kinase 2-Dependent Mechanism

@article{Rong2018BasicCP,
  title={Basic Calcium Phosphate Crystals Induce Osteoarthritis-Associated Changes in Phenotype Markers in Primary Human Chondrocytes by a Calcium/Calmodulin Kinase 2-Dependent Mechanism},
  author={Jing Rong and Bregtina Pool and Mark Zhu and Jacob T. Munro and Jillian Cornish and Geraldine Mccarthy and Nicola Dalbeth and Raewyn Poulsen},
  journal={Calcified Tissue International},
  year={2018},
  volume={104},
  pages={331-343}
}
Chondrocytes in osteoarthritis undergo a phenotype shift leading to increased production of cartilage-degrading enzymes. There are similarities between the phenotype of osteoarthritic chondrocytes and those of growth plate chondrocytes. Hydroxyapatite can promote chondrocyte differentiation in the growth plate. Basic calcium phosphate (BCP) crystals (which consist of hydroxyapatite, octacalcium apatite and tricalcium phosphate) are frequently found in osteoarthritic joints. The objective of… CONTINUE READING

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