Basement membranes: structure, assembly and role in tumour angiogenesis

@article{Kalluri2003BasementMS,
  title={Basement membranes: structure, assembly and role in tumour angiogenesis},
  author={Raghu Kalluri},
  journal={Nature Reviews Cancer},
  year={2003},
  volume={3},
  pages={422-433}
}
Key PointsVascular basement membranes (BMs) are important structural and functional components of all blood vessels/capillaries and have a crucial role in determining the progression of cancer.Constituents of vascular BMs, such as type IV collagen, laminin, SPARC and perlecan, have emerged as key regulators of angiogenesis.Type IV collagen and laminin can exert both positive and negative regulation of angiogenesis, depending on their structural integrity and assembly.Cryptic domains of type IV… CONTINUE READING
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