Basement membrane proteoglycans: from cellar to ceiling

@article{Iozzo2005BasementMP,
  title={Basement membrane proteoglycans: from cellar to ceiling},
  author={Renato V. Iozzo},
  journal={Nature Reviews Molecular Cell Biology},
  year={2005},
  volume={6},
  pages={646-656}
}
  • R. Iozzo
  • Published 1 August 2005
  • Biology
  • Nature Reviews Molecular Cell Biology
The biology of basement membrane proteoglycans extends far beyond the original notion of anionic filters. These complex molecules have dual roles as structural constituents of basement membranes and functional regulators of several growth-factor signalling pathways. As such, they are involved in angiogenesis and, consequently, in tumour progression and their partial or total absence causes several congenital defects that affect the musculoskeletal, cardiovascular and nervous systems. New… 
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505 Citations
Highly Influential Citations
35
Background Citations
221
Methods Citations
8
Results Citations
2

505 Citations

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The functional roles of the major heparan sulfate proteoglycans from basement membrane zones: perlecan, agrin and collagen XVIII, and on their roles in modulating cancer growth and angiogenesis are focused on.
Molecular organization of the basement membrane zone.
Basement membranes in development and disease.
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This review discusses recent findings regarding the structure of the BM and its roles in mediating the normal development of the embryo, and examines congenital diseases affecting the BM which impact embryonic development and health in later life.
Heparan sulphate proteoglycans fine-tune mammalian physiology
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Heparan sulphate proteoglycans reside on the plasma membrane of all animal cells studied so far and are a major component of extracellular matrices, which affects metabolism, transport, information transfer, support and regulation in all organ systems.
Peritoneal Proteoglycans: Much more than Ground Substance
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  • Biology, Medicine
    Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis
  • 2007
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The first part of this article reviews the biosynthesis of proteoglycans and their multifunctional roles in health and disease; the second part focuses on their putative roles in peritoneal homeostasis andperitoneal inflammation and fibrosis in the context of chronic peritoneAL dialysis and peritonitis.
Proteoglycans: from structural compounds to signaling molecules
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This review aims to summarize the multiple functions of proteoglycans with special emphasis on their intricate composition and the newly described signaling events in which these molecules play a key role.
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This review focuses on the expression, structure and function of proteoglycans in cancer and provides an overview of the field as well as specific examples of how these diverse molecules regulate tumor behavior.
Basement membrane components are key players in specialized extracellular matrices
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The latest research on these unique sECM and their components with a special emphasis on embryonic and adult stem cells and their niches is reviewed, opening the possibility that such matrices can fulfill distinct functions.
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