Basement membrane proteoglycans: from cellar to ceiling

  title={Basement membrane proteoglycans: from cellar to ceiling},
  author={Renato V. Iozzo},
  journal={Nature Reviews Molecular Cell Biology},
  • R. Iozzo
  • Published 1 August 2005
  • Biology
  • Nature Reviews Molecular Cell Biology
The biology of basement membrane proteoglycans extends far beyond the original notion of anionic filters. These complex molecules have dual roles as structural constituents of basement membranes and functional regulators of several growth-factor signalling pathways. As such, they are involved in angiogenesis and, consequently, in tumour progression and their partial or total absence causes several congenital defects that affect the musculoskeletal, cardiovascular and nervous systems. New… 
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