Basement membrane matrix modifies cytokine interactions between lung cancer cells and fibroblasts.

@article{Akashi2005BasementMM,
  title={Basement membrane matrix modifies cytokine interactions between lung cancer cells and fibroblasts.},
  author={Takumi Akashi and Junko Minami and Yuki Ishige and Yoshinobu Eishi and Touichiro Takizawa and Morio Koike and Masaki Yanagishita},
  journal={Pathobiology : journal of immunopathology, molecular and cellular biology},
  year={2005},
  volume={72 5},
  pages={250-9}
}
OBJECTIVE Proliferation of fibroblasts (desmoplastic reaction) in the lung adenocarcinomas is an important phenomenon that correlates with metastases and poor prognosis. Because basement membranes are often involved in the desmoplastic areas and many cytokines have binding capacity to basement membrane molecules, we hypothesized that basement membrane modify the paracrine effects between cancer cells and fibroblasts via the fibrogenic cytokines and this hypothesis was experimentally… CONTINUE READING

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