Basement membrane invasion by first trimester human trophoblast: requirement for branched complex-type Asn-linked oligosaccharides

@article{Yagel1990BasementMI,
  title={Basement membrane invasion by first trimester human trophoblast: requirement for branched complex-type Asn-linked oligosaccharides},
  author={Simcha Yagel and Robert S. Kerbel and P. K. Lala and T. Eldar-Gera and J. W. Dennis},
  journal={Clinical & Experimental Metastasis},
  year={1990},
  volume={8},
  pages={305-317}
}
Trophoblast cells of normal first trimester human placenta share with malignant tumor cells the ability for significant cellular proliferation and invasion of basement membranes. Because tumor cell metastasisin vivo and invasion of basement membranesin vitro have recently been shown to require the expression of-GIcNAcβ1–6 Manαl-6 Manβl-branched complex type Asn-linked oligosaccharides in tumor cell surface glycoproteins, we decided to determine if such structures were also necessary for… CONTINUE READING
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