Basement membrane influences intestinal epithelial cell growth and presents a barrier to the movement of macromolecules.


This work examines the potential drug delivery barrier of the basement membrane (BM) by assessing the permeability of select macromolecules and nanoparticles. The study further extends to probing the effect of BM on intestinal epithelial cell attachment and monolayer characteristics, including cell morphology. Serum-free cultured Caco-2 cells were grown on… (More)
DOI: 10.1016/j.yexcr.2014.02.022