Basement membrane extract preserves islet viability and activity in vitro by up-regulating α3 integrin and its signal.

@article{Miao2013BasementME,
  title={Basement membrane extract preserves islet viability and activity in vitro by up-regulating α3 integrin and its signal.},
  author={Gang Miao and Yanyang Zhao and Yao Li and Jingyong Xu and Huan Gong and Ruomei Qi and Jian Li and Junmin Wei},
  journal={Pancreas},
  year={2013},
  volume={42 6},
  pages={971-6}
}
OBJECTIVE Survival of transplanted islets is limited partly because of the disruption of the islet basement membrane (BM) occurring during isolation. We hypothesized that the embedment of BM extract (BME) could induce a viable cell mass and prolong islet functionality before transplantation. METHODS A special reconstituted BME that solidifies into a gel at 37°C was used to embed isolated islets in this study. The strategy was used to re-establish the interaction between the islets and peri… CONTINUE READING
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