Basement membrane complexes with biological activity.

@article{Kleinman1986BasementMC,
  title={Basement membrane complexes with biological activity.},
  author={Hynda K. Kleinman and M L Mcgarvey and J. Hassell and Vicki L. Star and F B Cannon and Gordon W. Laurie and Gail R. Martin},
  journal={Biochemistry},
  year={1986},
  volume={25 2},
  pages={312-8}
}
We have studied the reconstitution of basement membrane molecules from extracts prepared from the basement membrane of the EHS tumor. Under physiological conditions and in the presence of added type IV collagen and heparan sulfate proteoglycan, gellike structures form whose ultrastructure appears as interconnected thin sheets resembling the lamina dense zone of basement membrane. The major components of the reconstituted structures include laminin, type IV collagen, heparan sulfate proteoglycan… CONTINUE READING
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