Basement Membrane Sliding and Targeted Adhesion Remodels Tissue Boundaries During Uterine-vulval Attachment in C. elegans

  title={Basement Membrane Sliding and Targeted Adhesion Remodels Tissue Boundaries During Uterine-vulval Attachment in C. elegans},
  author={Shinji Ihara and Elliott J. Hagedorn and M. Morrissey and Q. Chi and Fumio Motegi and J. Kramer and David R Sherwood},
  journal={Nature cell biology},
  pages={641 - 651}
  • Shinji Ihara, Elliott J. Hagedorn, +4 authors David R Sherwood
  • Published 2011
  • Biology, Medicine
  • Nature cell biology
  • Large gaps in basement membrane occur at sites of cell invasion and tissue remodelling in development and cancer. Though never followed directly in vivo, basement membrane dissolution or reduced synthesis have been postulated to create these gaps. Using landmark photobleaching and optical highlighting of laminin and type IV collagen, we find that a new mechanism, basement membrane sliding, underlies basement membrane gap enlargement during uterine–vulval attachment in Caenorhabditis elegans… CONTINUE READING
    54 Citations

    Figures, Tables, and Topics from this paper

    Basement Membranes in the Worm: A Dynamic Scaffolding that Instructs Cellular Behaviors and Shapes Tissues.
    • 17
    • Highly Influenced
    • PDF
    B-LINK: a hemicentin, plakin, and integrin-dependent adhesion system that links tissues by connecting adjacent basement membranes.
    • 43
    • PDF
    Invadopodia and basement membrane invasion in vivo
    • 47
    • PDF
    Regulation of the basement membrane by epithelia generated forces.
    • K. Tanner
    • Medicine, Biology
    • Physical biology
    • 2012
    • 17
    Breaching and Opening Basement Membrane Barriers: The Anchor Cell Leads the Way
    • PDF
    Adaptive F-Actin Polymerization and Localized ATP Production Drive Basement Membrane Invasion in the Absence of MMPs.
    • 38
    • PDF
    SPARC promotes cell invasion in vivo by decreasing type IV collagen levels in the basement membrane
    • 8
    • PDF


    In Vivo Identification of Regulators of Cell Invasion Across Basement Membranes
    • 67
    • PDF
    Basement membrane remodeling is essential for Drosophila disc eversion and tumor invasion
    • 162
    • PDF
    Breaching the basement membrane: who, when and how?
    • 396
    Cell invasion through basement membranes: an anchor of understanding.
    • 59
    • PDF