Basement Membrane Sliding and Targeted Adhesion Remodels Tissue Boundaries During Uterine-vulval Attachment in C. elegans

@inproceedings{Ihara2011BasementMS,
  title={Basement Membrane Sliding and Targeted Adhesion Remodels Tissue Boundaries During Uterine-vulval Attachment in C. elegans},
  author={Shinji Ihara and Elliott J. Hagedorn and Meghan A Morrissey and Qiuyi 8 Chi and Fumio Motegi and James M. Kramer and David R Sherwood},
  booktitle={Nature Cell Biology},
  year={2011}
}
Large gaps in basement membrane occur at sites of cell invasion and tissue remodelling in development and cancer. Though never followed directly in vivo, basement membrane dissolution or reduced synthesis have been postulated to create these gaps. Using landmark photobleaching and optical highlighting of laminin and type IV collagen, we find that a new mechanism, basement membrane sliding, underlies basement membrane gap enlargement during uterine–vulval attachment in Caenorhabditis elegans… CONTINUE READING