Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy.


BACKGROUND Recent studies have suggested a high prevalence of cardiac amyloidosis (CAm) in heart failure (HF) patients. CAm might be underdiagnosed owing to low clinical suspicion. METHODS AND RESULTS We performed retrospective analysis of 259 patients with HF and ejection fraction (EF) ≥50% referred for endomyocardial biopsy. Seventy-three (28%) had CAm. Multivariable independent predictors of CAm were identified. Over a mean follow-up of 2.6 ± 3.3 years, CAm patients had worse survival than those without (1.5 y vs 6.3 y; log rank P < .0001). CONCLUSIONS Clinicians should be suspicious of CAm in patients with EF 50%-75%, >50 years of age, BMI <30 kg/m2, peripheral neuropathy, Sokolow-Lyon index ≤15 mm, and septal wall thickness ≥1.4 cm.

DOI: 10.1016/j.cardfail.2016.12.006

Cite this paper

@article{Ton2017BaselineCP, title={Baseline Characteristics Predict the Presence of Amyloid on Endomyocardial Biopsy.}, author={Van-Khue Ton and Aditya Bhonsale and Nisha Aggarwal Gilotra and Marc K. Halushka and Charles Steenbergen and Johana R Almansa and Emily E Brown and Ryan J Tedford and Ilan S. Wittstein and Kavita G Sharma and Stuart D . Russell and Daniel P Judge}, journal={Journal of cardiac failure}, year={2017}, volume={23 4}, pages={340-344} }