Base substitutions, length differences and DNA strand asymmetries in the human G gamma and A gamma fetal globin gene region.

@article{Smithies1981BaseSL,
  title={Base substitutions, length differences and DNA strand asymmetries in the human G gamma and A gamma fetal globin gene region.},
  author={O. Smithies and William R. Engels and J. Devereux and Jerry L. Slightom and S. H. Shen},
  journal={Cell},
  year={1981},
  volume={26 3 Pt 1},
  pages={345-53}
}
We have studied differences arising subsequent to the 5 kilobase pair (kb) duplication that led to the human G gamma and A gamma fetal globin genes. The local occurrence of base substitutions in the duplicated 5 kb region correlates positively with the local AT base pair content. This correlation also occurs in two mouse beta-globin genes and in two mouse immunoglobulin genes. The relationship is valid for transcribed or nontranscribed DNA and for DNA that contains only coding sequences. Length… CONTINUE READING
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