Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine†

@inproceedings{Bhamra2012BasepairingPP,
  title={Base-pairing preferences, physicochemical properties and mutational behaviour of the DNA lesion 8-nitroguanine†},
  author={Inder Bhamra and Patricia Compagnone-Post and Ian A. O’Neil and Lesley Ann Iwanejko and Andrew Derek Bates and Richard Cosstick},
  booktitle={Nucleic acids research},
  year={2012}
}
8-Nitro-2'-deoxyguanosine (8-nitrodG) is a relatively unstable, mutagenic lesion of DNA that is increasingly believed to be associated with tissue inflammation. Due to the lability of the glycosidic bond, 8-nitrodG cannot be incorporated into oligodeoxynucleotides (ODNs) by chemical DNA synthesis and thus very little is known about its physicochemical properties and base-pairing preferences. Here we describe the synthesis of 8-nitro-2'-O-methylguanosine, a ribonucleoside analogue of this lesion… CONTINUE READING

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