Base pairing constraints drive structural epistasis in ribosomal RNA sequences.

@article{Dutheil2010BasePC,
  title={Base pairing constraints drive structural epistasis in ribosomal RNA sequences.},
  author={Julien Y Dutheil and Fabrice Jossinet and E. Westhof},
  journal={Molecular biology and evolution},
  year={2010},
  volume={27 8},
  pages={1868-76}
}
It has long been accepted that the structural constraints stemming from the 3D structure of ribosomal RNA (rRNA) lead to coevolution through compensating mutations between interacting sites. State-of-the-art methods for detecting coevolving sites, however, while reaching high levels of specificity and sensitivity for Watson-Crick (WC) pairs of the helices defining the secondary structure, only scarcely reveal tertiary interactions occurring at the level of the 3D structure. In order to… CONTINUE READING
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