Base pair opening dynamics of a 2-aminopurine substituted Eco RI restriction sequence and its unsubstituted counterpart in oligonucleotides.

@article{Lycksell1987BasePO,
  title={Base pair opening dynamics of a 2-aminopurine substituted Eco RI restriction sequence and its unsubstituted counterpart in oligonucleotides.},
  author={P O Lycksell and Astrid Gr{\"a}slund and F. Claesens and Larry W. McLaughlin and Ulrica Larsson and Rudolf W. Rigler},
  journal={Nucleic acids research},
  year={1987},
  volume={15 21},
  pages={9011-25}
}
Studies of 1H NMR selective saturation recovery were performed to determine the imino proton exchange with solvent water of the base pairs in the Eco RI endonuclease recognition sequence GAATTC, placed at the center of self-complementary decamer and dodecamer oligonucleotides. In one oligonucleotide the innermost adenine was replaced by the fluorescent base analogue 2-aminopurine (2AP). From the measurements at different concentrations of TRIS buffer acting as proton exchange catalyst, base… CONTINUE READING
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