Base pair mismatch recognition using plasmon resonant particle labels.

  title={Base pair mismatch recognition using plasmon resonant particle labels.},
  author={Steven J. Oldenburg and Christine C Genick and Keith A Clark and David A. Schultz},
  journal={Analytical biochemistry},
  volume={309 1},
We demonstrate the use of silver plasmon resonant particles (PRPs), as reporter labels, in a microarray-based DNA hybridization assay in which we screen for a known polymorphic site in the breast cancer gene BRCA1. PRPs (40-100 nm in diameter) image as diffraction-limited points of colored light in a standard microscope equipped with dark-field illumination, and can be individually identified and discriminated against background scatter. Rather than overall intensity, the number of PRPs counted… CONTINUE READING
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