Base-line and postthermal injury plasma histamine in rats.

@article{Yurt1986BaselineAP,
  title={Base-line and postthermal injury plasma histamine in rats.},
  author={Roger Yurt and Basil A. Pruitt},
  journal={Journal of applied physiology},
  year={1986},
  volume={60 5},
  pages={1782-8}
}
Although plasma histamine concentration has been reported to increase after thermal injury in the rat to as much as 100-fold over normal human plasma levels, the pathophysiological significance and relevance to human disease is questionable. Lack of confidence in the rat as a model of histamine-mediated disease is based on reports that normal rat base-line plasma histamine concentration exceeds that of human plasma by 20- to 70-fold. The present study confirms that high concentrations of… CONTINUE READING

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