Base excision repair pathway genes polymorphism in prostate and bladder cancer risk in North Indian population.

@article{Mittal2012BaseER,
  title={Base excision repair pathway genes polymorphism in prostate and bladder cancer risk in North Indian population.},
  author={Rama Devi Mittal and Raju Kumar Mandal and Ruchika Gangwar},
  journal={Mechanisms of ageing and development},
  year={2012},
  volume={133 4},
  pages={127-32}
}
PURPOSE Carcinogens causes DNA damage, including oxidative lesions that are removed efficiently by the base excision repair (BER) pathway. Variations in BER genes may reduce DNA repair capacity, leading to development of urological cancers. METHODS This study included 195 prostate cancer (PCa) and 212 bladder cancer (BC) patients and 250 controls who had been frequency matched by age, sex, and ethnicity. We genotyped XRCC1 Exon 6 (C>T), 9 (G>A), 10 (G>A), OGG1 Exon 7 (C>G) and APE1 Exon 5 (T… CONTINUE READING
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