Base excision repair of 8-oxoG in dinucleosomes

  title={Base excision repair of 8-oxoG in dinucleosomes},
  author={Herv{\'e} Menoni and Manu Shubhdarshan Shukla and V{\'e}ronique Gerson and Stefan I Dimitrov and Dimitar Angelov},
  booktitle={Nucleic acids research},
In this work we have studied the effect of chromatin structure on the base excision repair (BER) efficiency of 8-oxoG. As a model system we have used precisely positioned dinucleosomes assembled with linker histone H1. A single 8-oxoG was inserted either in the linker or the core particle DNA within the dinucleosomal template. We found that in the absence… CONTINUE READING