Base excision repair in nucleosome substrates

  title={Base excision repair in nucleosome substrates},
  author={Indu Jagannathan and Hope A. Cole and Jeffrey J Hayes},
  journal={Chromosome Research},
Eukaryotic cells must repair DNA lesions within the context of chromatin. Much of our current understanding regarding the activity of enzymes involved in DNA repair processes comes from in-vitro studies utilizing naked DNA as a substrate. Here we review current literature investigating how enzymes involved in base excision repair (BER) contend with… CONTINUE READING